This project aims to address the challenges associated with commonly used oral hygiene products. Chlorhexidine mouthwash, along with popular ingredients like xylitol, fluoride, and triclosan, has been linked to adverse effects such as hypogeusia, hypersensitivity, mucosal lesions, and tooth staining. Additionally, products containing SLS or triclosan can irritate gums and soft tissues, while those with high alcohol content may cause a burning sensation and disrupt the normal oral flora. Moreover, the overuse of antibiotics in oral treatments raises concerns about the development of bacterial resistance. The project aims to develop alternative oral hygiene solutions that are safe, effective, and free from these adverse side effects.
1) Chlorhexidine mouthwash - lead to hypogeusia, hypersensitivity, mucosal lesion, and tooth staining
2) Chlorhexidine, xylitol, fluoride and triclosan are popularly used - risk for toxicity
3) Contains SLS / triclosan - irritate gums and soft tissues
4) High alcohol content - burning sensation, kill normal flora
5) Overuse of antibiotics in oral treatment - bacterial resistance
1) Using safe ingredients: Botanical flavoring agent (peppermint oil)- pleasant taste, antibacteria
2) Using safe ingredients: Sweetener and surfactant from food grade – sorbitol, Tween 20 (no SLS and triclosan- no gums and soft tissues irritation)
3) No harmful preservatives (no paraben)- sodium benzoate/potassium sorbate
4) No chlorohexidine – no hypogeusia, no hypersensitivity, mucosal lesion, and no tooth staining
5) No artificial color/synthetic additives
6) Alcohol free – no burning sensation, doesn’t kill normal flora
7) Andrographis paniculata plant extract-antibacterial onto oral pathogens, anti-inflammatory. Heavy metals free and non-toxic
1) Individuals that interested in using natural/organic product
2) Individual seeking for non-toxic mouthwash
3) Individual with sesitive gums/oral health problem
1) Community: Current use of chemical-based mouthwash resulted in unwanted side effects onto oral cavity. The development of AP’ DENT will be the solution for these problems.
2) Academia: New knowledge on the antibacterial activities of AP extract onto oral pathogens, its toxicity and stability study.
3) Economy: Economic potential to the AP plant farmers in providing raw materials for AP’ DENT production.
4) Industry: Can attract investor and industry to produce alternative mouthwash, AP’ DENT product for oral hygiene used.
5) Environment: AP’ DENT is made from natural ingredients and does not contain harmful chemicals, making it more environmental friendly option.